Method

Fourteen lean subjects, seven men and seven women with normal body weight (within 10 per cent of the accepted norm for the age, sex, and height of the patient) were admitted to the hospital for this study. The patients were kept at rest with activity being limited to their hospital room. They were allowed to sit in the chair, go to the bathroom, but otherwise remained at rest. They were allowed water ad lib, tea and/or black coffee unsweetened. Twenty-four hour urine collections were obtained and daily venous blood specimens were taken each morning. The hospital is air conditioned and the temperature maintained at 72'F. with constant humidity. Total ketones were determined by the method of Bloom3 as modified by Lyon and Results of all ketone determinations were expressed as 623