Long-acting medications for the hyperkinetic disorders: a systematic review and European treatment guideline

T Banaschewski, D Coghill, P Santosh…�- European child &�…, 2006 - Springer
T Banaschewski, D Coghill, P Santosh, A Zuddas, P Asherson, J Buitelaar, M Danckaerts…
European child & adolescent psychiatry, 2006Springer
A systematic review of published and unpublished data on the use of long-acting
medications in ADHD and hyperkinetic disorder is reported, giving effect sizes and numbers-
to-treat for extended-release stimulant preparations and atomoxetine (ATX). A panel of
experts from several European countries used the review to make recommendations about
the use of these drugs in practice, and conclusions are reported:(1) Long-acting
preparations should be available and used;(2) They should not replace short-acting drugs�…
Abstract
A systematic review of published and unpublished data on the use of long-acting medications in ADHD and hyperkinetic disorder is reported, giving effect sizes and numbers-to-treat for extended-release stimulant preparations and atomoxetine (ATX). A panel of experts from several European countries used the review to make recommendations about the use of these drugs in practice, and conclusions are reported: (1) Long-acting preparations should be available and used; (2) They should not replace short-acting drugs (which will be the initial treatment for many children for reasons of cost and flexibility of dosing). Individual clinical choice is needed. (3) Both ATX and extended-release preparations of stimulants should be available. The choice will depend upon the circumstances, and detailed recommendations are made.
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