[HTML][HTML] Heparin-binding protein measurement improves the prediction of severe infection with organ dysfunction in the emergency department
A Linder, R Arnold, JH Boyd, M Zindovic…�- Critical care�…, 2015 - journals.lww.com
Objectives: Early identification of patients with infection and at risk of developing severe
disease with organ dysfunction remains a difficult challenge. We aimed to evaluate and
validate the heparin-binding protein, a neutrophil-derived mediator of vascular leakage, as a
prognostic biomarker for risk of progression to severe sepsis with circulatory failure in a
multicenter setting. Design: A prospective international multicenter cohort study. Setting:
Seven different emergency departments in Sweden, Canada, and the United States�…
disease with organ dysfunction remains a difficult challenge. We aimed to evaluate and
validate the heparin-binding protein, a neutrophil-derived mediator of vascular leakage, as a
prognostic biomarker for risk of progression to severe sepsis with circulatory failure in a
multicenter setting. Design: A prospective international multicenter cohort study. Setting:
Seven different emergency departments in Sweden, Canada, and the United States�…