A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease

A Mente, L de Koning, HS Shannon…�- Archives of internal�…, 2009 - jamanetwork.com
Background Although a wealth of literature links dietary factors and coronary heart disease
(CHD), the strength of the evidence supporting valid associations has not been evaluated
systematically in a single investigation. Methods We conducted a systematic search of
MEDLINE for prospective cohort studies or randomized trials investigating dietary exposures
in relation to CHD. We used the Bradford Hill guidelines to derive a causation score based
on 4 criteria (strength, consistency, temporality, and coherence) for each dietary exposure in�…