Associations of Serum Perfluoroalkyl Substances and Placental Human Chorionic Gonadotropin in Early Pregnancy, Measured in the UPSIDE Study in Rochester�…
Background: Per-and polyfluoroalkyl substances (PFAS) are widely detected in pregnant
women and associated with adverse outcomes related to impaired placental function.
Human chorionic gonadotropin (hCG) is a dimeric glycoprotein hormone that can indicate
placental toxicity. Objectives: Our aim was to quantify the association of serum PFAS with
placental hCG, measured as an intact molecule (hCG), as free alpha-(hCG α) and beta-
subunits (hCG β), and as a hyperglycosylated form (h-hCG), and evaluate effect measure�…
women and associated with adverse outcomes related to impaired placental function.
Human chorionic gonadotropin (hCG) is a dimeric glycoprotein hormone that can indicate
placental toxicity. Objectives: Our aim was to quantify the association of serum PFAS with
placental hCG, measured as an intact molecule (hCG), as free alpha-(hCG α) and beta-
subunits (hCG β), and as a hyperglycosylated form (h-hCG), and evaluate effect measure�…