[HTML][HTML] Direct acetylation of the estrogen receptor α hinge region by p300 regulates transactivation and hormone sensitivity
C Wang, M Fu, RH Angeletti, L Siconolfi-Baez…�- Journal of Biological�…, 2001 - ASBMB
Regulation of nuclear receptor gene expression involves dynamic and coordinated
interactions with histone acetyl transferase (HAT) and deacetylase complexes. The estrogen
receptor (ERα) contains two transactivation domains regulating ligand-independent and-
dependent gene transcription (AF-1 and AF-2 (activation functions 1 and 2)). ERα-regulated
gene expression involves interactions with cointegrators (eg p300/CBP, P/CAF) that have
the capacity to modify core histone acetyl groups. Here we show that the ERα is acetylated�…
interactions with histone acetyl transferase (HAT) and deacetylase complexes. The estrogen
receptor (ERα) contains two transactivation domains regulating ligand-independent and-
dependent gene transcription (AF-1 and AF-2 (activation functions 1 and 2)). ERα-regulated
gene expression involves interactions with cointegrators (eg p300/CBP, P/CAF) that have
the capacity to modify core histone acetyl groups. Here we show that the ERα is acetylated�…