The episodic secretion of gonadotropin-releasing hormone (GnRH) is crucial for fertility, but
the cellular mechanisms and network properties generating GnRH pulses are not well
understood. We will explore three primary aspects of this intermittent hormonal signal: the
source of rhythm (s), the possible mechanisms comprising oscillator (s), and how GnRH
neurons are synchronized to produce a pulse of hormone release into the pituitary portal
blood. Current knowledge will be reviewed, and hypotheses and working models proposed�…