Catechol‐O‐Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta‐Analysis of Previously Published�…
E Collantoni, M Solmi, D Gallicchio…�- European Eating�…, 2017 - Wiley Online Library
European Eating Disorders Review, 2017•Wiley Online Library
Objectives We investigated whether catechol‐O‐methyltransferase (COMT) Val158Met
polymorphism is associated with eating disorders (EDs). Methods We conducted a
systematic literature search of studies published until 15 January 2017 and added data from
the Italian 'Biobanca Veneta per i Disturbi Alimentari'biobank, performing a meta‐analysis
comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa
(AN) or bulimia nervosa (BN) patients versus controls. Results Ten studies plus Biobanca�…
polymorphism is associated with eating disorders (EDs). Methods We conducted a
systematic literature search of studies published until 15 January 2017 and added data from
the Italian 'Biobanca Veneta per i Disturbi Alimentari'biobank, performing a meta‐analysis
comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa
(AN) or bulimia nervosa (BN) patients versus controls. Results Ten studies plus Biobanca�…
Objectives
We investigated whether catechol‐O‐methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs).
Methods
We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian ‘Biobanca Veneta per i Disturbi Alimentari’ biobank, performing a meta‐analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls.
Results
Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96–1.04, p‐values: 0.46–0.97, I2 = 0%] and when analysing separately patients with AN (ORs: 0.94–1.04, p‐values: 0.31–0.61, I2 = 0%) or BN (ORs: 0.80–1.09, p‐values: 0.28–0.64, I2 = 0–44%).
Conclusions
Meta‐analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright � 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
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