Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data
MK Brandys, MCT Slof-Op't Landt…�- Psychiatric�…, 2012 - journals.lww.com
Objectives This study aimed to test the association between the Val158Met polymorphism
(rs4680) of the catechol-O-methyl transferase gene and anorexia nervosa (AN). Methods
First, an association study on two cohorts (306 cases and 1009 controls from Utrecht, and
174 cases and 466 controls from Leiden/NTR) was performed. Subsequently, the results
were integrated into a meta-analysis, together with all the case–control and family-based
studies, which were testing the same hypothesis and were available in the literature�…
(rs4680) of the catechol-O-methyl transferase gene and anorexia nervosa (AN). Methods
First, an association study on two cohorts (306 cases and 1009 controls from Utrecht, and
174 cases and 466 controls from Leiden/NTR) was performed. Subsequently, the results
were integrated into a meta-analysis, together with all the case–control and family-based
studies, which were testing the same hypothesis and were available in the literature�…