Estrogen receptors (ERs) α and β exist as nuclear, cytoplasmic, and membrane cellular
pools in a wide variety of organs. The relative contributions of each ERα pool to in vivo
phenotypes resulting from estrogen signaling have not been determined. To address this,
we generated a transgenic mouse expressing only a functional E domain of ERα at the
plasma membrane (MOER). Cells isolated from many organs showed membrane only
localized E domain of ERα and no other receptor pools. Liver cells from MOER and wild type�…