Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism or gene ism
EP Noble, K Blum, T Ritchie…�- Archives of general�…, 1991 - jamanetwork.com
• The allelic association of the human D 2 dopamine receptor gene with the binding
characteristics of the D 2 dopamine receptor was determined in 66 brains of alcoholic and
nonalcoholic subjects. In a blinded experiment, DNA from the cerebral cortex was treated
with the restriction endonuclease Taql and probed with a 1.5-kilobase (kb) digest of a clone
(XhD2G1) of the human D 2 dopamine receptor gene. The binding characteristics (K d
[binding affinity] and B max [number of binding sites]) of the D 2 dopamine receptor were�…
characteristics of the D 2 dopamine receptor was determined in 66 brains of alcoholic and
nonalcoholic subjects. In a blinded experiment, DNA from the cerebral cortex was treated
with the restriction endonuclease Taql and probed with a 1.5-kilobase (kb) digest of a clone
(XhD2G1) of the human D 2 dopamine receptor gene. The binding characteristics (K d
[binding affinity] and B max [number of binding sites]) of the D 2 dopamine receptor were�…