Incidence and prevalence of central precocious puberty in Korea: an epidemiologic study based on a national database
YJ Kim, A Kwon, MK Jung, KE Kim, J Suh…�- The Journal of�…, 2019 - Elsevier
The Journal of pediatrics, 2019•Elsevier
Objectives To investigate the prevalence and incidence of central precocious puberty in
Korea using claims data provided by the Health Insurance Review and Assessment Service
in Korea as the population-based epidemiologic study. Study design In this national registry-
based, longitudinal, epidemiologic study, patients who were registered with an International
Classifications of Diseases, Tenth Revision diagnosis of central precocious puberty (E22. 8
according to International Classifications of Diseases, Tenth Revision) and treated with�…
Korea using claims data provided by the Health Insurance Review and Assessment Service
in Korea as the population-based epidemiologic study. Study design In this national registry-
based, longitudinal, epidemiologic study, patients who were registered with an International
Classifications of Diseases, Tenth Revision diagnosis of central precocious puberty (E22. 8
according to International Classifications of Diseases, Tenth Revision) and treated with�…
Objectives
To investigate the prevalence and incidence of central precocious puberty in Korea using claims data provided by the Health Insurance Review and Assessment Service in Korea as the population-based epidemiologic study.
Study design
In this national registry-based, longitudinal, epidemiologic study, patients who were registered with�an International Classifications of Diseases, Tenth Revision diagnosis of central precocious puberty (E22.8�according to International Classifications of Diseases, Tenth Revision) and treated with gonadotropin-releasing hormone agonist were included. We assessed the age- and sex-specific prevalence and incidence rates of central precocious puberty in Korea from 2008 to�2014.
Results
A total of 37 890 girls and 1220 boys were newly registered with a diagnosis of central precocious puberty from 2008 to 2014. The overall incidence of central precocious puberty during the study period was 122.8 per 100 000 persons (girls, 262.8; boys, 7.0). The overall prevalence of central precocious puberty during the study period was 193.2 per 100 000 persons (girls, 410.6; boys, 10.9). The incidence and prevalence of central precocious puberty steeply increased during the study period in both girls and boys.
Conclusions
This epidemiologic study, based on a national registry that included Korean children, demonstrated that the incidence and prevalence rates of central precocious puberty were high and increased steeply during the study period. Further investigations to determine the underlying causes for this rapid increase in central precocious puberty are needed.
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