Trends in the incidence of central precocious puberty and normal variant puberty among children in Denmark, 1998 to 2017
EV Br�uner, AS Busch, C Eckert-Lind, T Koch…�- JAMA network�…, 2020 - jamanetwork.com
Importance There has been a worldwide secular trend toward earlier onset of puberty in the
general population. However, it remains uncertain if these changes are paralleled with
increased incidence of central precocious puberty (CPP) and normal variant puberty (ie,
premature thelarche [PT] and premature adrenarche [PA]) because epidemiological
evidence on the time trends in the incidence of these puberty disorders is scarce. Objective
To provide valid epidemiological data on the 20-year secular trend in the incidence rates of�…
general population. However, it remains uncertain if these changes are paralleled with
increased incidence of central precocious puberty (CPP) and normal variant puberty (ie,
premature thelarche [PT] and premature adrenarche [PA]) because epidemiological
evidence on the time trends in the incidence of these puberty disorders is scarce. Objective
To provide valid epidemiological data on the 20-year secular trend in the incidence rates of�…