Context Alcohol dependence is a common neuropsychiatric disorder with high heritability.
However, genetic association studies on alcohol dependence are often troubled by
nonreplication. The use of intermediate phenotypes may help make clear the mode of action
of various candidate genes and improve the reproducibility of genetic association studies.
Objective To test central dopamine receptor sensitivity as an intermediate phenotype for
alcohol dependence, specifically evaluating the hypothesis that the dopaminergic genes�…