[HTML][HTML] Which dopamine polymorphisms are functional? Systematic review and meta-analysis of COMT, DAT, DBH, DDC, DRD1–5, MAOA, MAOB, TH, VMAT1, and�…
Background Many polymorphisms in dopamine genes are reported to affect cognitive,
imaging, or clinical phenotypes. It is often inferred or assumed that such associations are
causal, mediated by a direct effect of the polymorphism on the gene product itself. However,
the supporting evidence is not always clear. Methods We conducted systematic reviews and
meta-analyses to assess the empirical evidence for functional polymorphisms in genes
encoding dopaminergic enzymes (COMT, DBH, DDC, MAOA, MAOB, and TH), dopamine�…
imaging, or clinical phenotypes. It is often inferred or assumed that such associations are
causal, mediated by a direct effect of the polymorphism on the gene product itself. However,
the supporting evidence is not always clear. Methods We conducted systematic reviews and
meta-analyses to assess the empirical evidence for functional polymorphisms in genes
encoding dopaminergic enzymes (COMT, DBH, DDC, MAOA, MAOB, and TH), dopamine�…