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Diabetic nephropathy is one of the most common and severe complications of
diabetes mellitus, affecting one in every five patients suffering from diabetes. Despite
extensive research, the exact pathogenesis of diabetic nephropathy is still unclear�…

Organ fibrosis represents a dysregulated, maladaptive wound repair response that
results in progressive disruption of normal tissue architecture leading to detrimental
deterioration in physiological function, and significant morbidity/mortality. Fibrosis is�…

Diabetic kidney disease (DKD) is a major microvascular complication of diabetes,
and hyperglycemic memory associated with diabetes carries the risk of disease
occurrence, even after the termination of blood glucose injury. The existence of�…

Integrins are cellular receptors that bind the extracellular matrix (ECM) and facilitate
the transduction of biochemical and biophysical microenvironment cues into cellular
responses. Upon engaging the ECM, integrin heterodimers must rapidly strengthen�…

Many studies have highlighted the importance of moderate exercise. While it can
attenuate diabetic kidney disease, its mechanism has remained unclear. The level of
myokine irisin in plasma increases during exercise. We found that irisin was�…

Background: MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) play key
roles in diabetic kidney disease (DKD). The miR-379 megacluster of miRNAs and its
host transcript lnc-megacluster (lncMGC) are regulated by transforming growth factor�…

Atrazine (ATR) is a widely used agricultural herbicide, and its accumulation in soil
and water can cause various environmental health problems. ATR has neurotoxic
effects on dopaminergic neurons, which can lead to a Parkinson's disease (PD)-like�…

Hyperglycemia can also induce the production of free radicals and the progression of
inflammatory reactions. The aim of this study is to explore the potential anti-oxidant
and anti-inflammatory mechanisms of luteolin in the treatment of diabetic�…

Placenta accreta spectrum (PAS) is one of the major causes of maternal morbidity
and mortality worldwide with increasing incidence. PAS refers to a group of
pathological conditions ranging from the abnormal attachment of the placenta to the�…

There has been major progress in understanding pathogenic mechanisms in
systemic sclerosis (SSc) at a molecular and cellular level. This has permitted key
pathways, mediators, and cell types that may be central to the disease to be better�…