Sample results107 results in the last year.
Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight
Neurodegenerative diseases are the most common cause of dementia. Although
their underlying molecular pathologies have been identified, there is substantial
heterogeneity in the patterns of progressive brain alterations across and within these�…
their underlying molecular pathologies have been identified, there is substantial
heterogeneity in the patterns of progressive brain alterations across and within these�…
Towards a biologically annotated brain connectome
The brain is a network of interleaved neural circuits. In modern connectomics, brain
connectivity is typically encoded as a network of nodes and edges, abstracting away
the rich biological detail of local neuronal populations. Yet biological annotations for�…
connectivity is typically encoded as a network of nodes and edges, abstracting away
the rich biological detail of local neuronal populations. Yet biological annotations for�…
Toward best practices for imaging transcriptomics of the human brain
Modern brainwide transcriptional atlases provide unprecedented opportunities for
investigating the molecular correlates of brain organization, as quantified using
noninvasive neuroimaging. However, integrating neuroimaging data with�…
investigating the molecular correlates of brain organization, as quantified using
noninvasive neuroimaging. However, integrating neuroimaging data with�…
BrainStat: A toolbox for brain-wide statistics and multimodal feature associations
Abstract Analysis and interpretation of neuroimaging datasets has become a
multidisciplinary endeavor, relying not only on statistical methods, but increasingly
on associations with respect to other brain-derived features such as gene�…
multidisciplinary endeavor, relying not only on statistical methods, but increasingly
on associations with respect to other brain-derived features such as gene�…
Integrating multimodal and multiscale connectivity blueprints of the human cerebral cortex in health and disease
The brain is composed of disparate neural populations that communicate and
interact with one another. Although fiber bundles, similarities in molecular
architecture, and synchronized neural activity all reflect how brain regions potentially�…
interact with one another. Although fiber bundles, similarities in molecular
architecture, and synchronized neural activity all reflect how brain regions potentially�…
In vivo mapping of pharmacologically induced functional reorganization onto the human brain's neurotransmitter landscape
To understand how pharmacological interventions can exert their powerful effects on
brain function, we need to understand how they engage the brain's rich
neurotransmitter landscape. Here, we bridge microscale molecular�…
brain function, we need to understand how they engage the brain's rich
neurotransmitter landscape. Here, we bridge microscale molecular�…
Patient-specific models link neurotransmitter receptor mechanisms with motor and visuospatial axes of Parkinson's disease
Parkinson's disease involves multiple neurotransmitter systems beyond the classical
dopaminergic circuit, but their influence on structural and functional alterations is not
well understood. Here, we use patient-specific causal brain modeling to identify�…
dopaminergic circuit, but their influence on structural and functional alterations is not
well understood. Here, we use patient-specific causal brain modeling to identify�…
Covariance patterns between sleep health domains and distributed intrinsic functional connectivity
Sleep health is both conceptually and operationally a composite concept containing
multiple domains of sleep. In line with this, high dependence and interaction across
different domains of sleep health encourage a transition in sleep health research�…
multiple domains of sleep. In line with this, high dependence and interaction across
different domains of sleep health encourage a transition in sleep health research�…
Cerebral chemoarchitecture shares organizational traits with brain structure and function
Chemoarchitecture, the heterogeneous distribution of neurotransmitter transporter
and receptor molecules, is a relevant component of structure–function relationships
in the human brain. Here, we studied the organization of the receptome, a measure�…
and receptor molecules, is a relevant component of structure–function relationships
in the human brain. Here, we studied the organization of the receptome, a measure�…
Homotopic functional connectivity disruptions in schizophrenia and their associated gene expression
It has been revealed that abnormal voxel-mirrored homotopic connectivity (VMHC) is
present in patients with schizophrenia, yet there are inconsistencies in the relevant
findings. Moreover, little is known about their association with brain gene expression�…
present in patients with schizophrenia, yet there are inconsistencies in the relevant
findings. Moreover, little is known about their association with brain gene expression�…