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Memory is essential in defining our identity by guiding behavior based on past
experiences. However, aging leads to declining memory, disrupting older adult's
lives. Memories are encoded through experience-dependent modifications of�…

Noradrenergic and cholinergic systems are among the most vulnerable brain
systems in neuropsychiatric diseases of ageing, including Alzheimer's disease,
Parkinson's disease, Lewy body dementia, and progressive supranuclear palsy. As�…

Our daily experiences unfold continuously, but we remember them as a series of
discrete events through a process called event segmentation. Prominent theories of
event segmentation suggest that event boundaries in memory are triggered by�…

Expressions such as 'sleep on it'refer to the resolution of distressing experiences
across a night of sound sleep. Sleep is an active state during which the brain
reorganizes the synaptic connections that form memories. This Perspective proposes�…

Increasing the therapeutic potential and reducing the side effects of US Food and
Drug Administration–approved glucagon-like peptide-1 receptor (GLP-1R) agonists
used to treat obesity require complete characterization of the central mechanisms�…

How is the massive dimensionality and complexity of the microscopic constituents of
the nervous system brought under sufficiently tight control so as to coordinate
adaptive behaviour? A powerful means for striking this balance is to poise neurons�…

The locus coeruleus (LC) is a small brainstem structure located in the lower pons
and is the main source of noradrenaline (NA) in the brain. Via its phasic and tonic
firing, it modulates cognition and autonomic functions and is involved in the brain's�…

Hindbrain adrenergic/noradrenergic nuclei facilitate endocrine and autonomic
responses to physical and psychological challenges. Neurons that synthesize
adrenaline and noradrenaline target hypothalamic structures to modulate endocrine�…

Although the arousal elicited by emotional stimuli, similarly to valence, is an
integrative part of emotion theories, previous studies and reviews mostly focused on
the valence of a stimulus and rarely investigated the role of arousal. Here, I�…

Summary Layer 1 (L1) of the neocortex acts as a nexus for the collection and
processing of widespread information. By integrating ascending inputs with
extensive top-down activity, this layer likely provides critical information regulating�…