Most relevant results6 results in the last year.
A cerebro-cerebellar network for learning visuomotor associations
Consensus is rapidly building to support a role for the cerebellum beyond motor
function, but its contributions to non-motor learning remain poorly understood. Here,
we provide behavioral, anatomical and computational evidence to demonstrate a�…
function, but its contributions to non-motor learning remain poorly understood. Here,
we provide behavioral, anatomical and computational evidence to demonstrate a�…
Early molecular events of autosomal‐dominant Alzheimer's disease in marmosets with PSEN1 mutations
INTRODUCTION Fundamental questions remain about the key mechanisms that
initiate Alzheimer's disease (AD) and the factors that promote its progression. Here
we report the successful generation of the first genetically engineered marmosets�…
initiate Alzheimer's disease (AD) and the factors that promote its progression. Here
we report the successful generation of the first genetically engineered marmosets�…
Characterizing plasma biomarkers of Alzheimer's Disease in aging marmosets and genetically engineered PSEN1 mutation carriers.
Abstract Background Alzheimer's Disease (AD) is a progressive disease that
presents as a continuum evolution from preclinical AD to mild cognitive impairment
and, ultimately, dementia. The phenotypic characterization of AD was unified under a�…
presents as a continuum evolution from preclinical AD to mild cognitive impairment
and, ultimately, dementia. The phenotypic characterization of AD was unified under a�…
Genomic analysis of fibroblasts from marmosets carrying early‐onset Alzheimer's disease mutations in PSEN1
Background Alzheimer's disease (AD) is the most prevalent form of dementia and
remains generally untreatable. The slow, age‐related development of AD and
inaccessibility of early‐stage brain tissue has limited our understanding of its origins�…
remains generally untreatable. The slow, age‐related development of AD and
inaccessibility of early‐stage brain tissue has limited our understanding of its origins�…
Assessing amyloid plaque burden in aging marmosets and genetically engineered PSEN1 mutation carriers using 11C‐PiB PET
Background There is an urgent need to develop novel animal models to investigate
the underlying cellular and molecular root causes of the pathogenesis and
progression of AD. Our group has worked to establish the common marmoset as the�…
the underlying cellular and molecular root causes of the pathogenesis and
progression of AD. Our group has worked to establish the common marmoset as the�…
Production of a PSEN1 genetically engineered marmoset model of early‐onset Alzheimer's Disease
Background The lack of an adequate animal model of Alzheimer's disease (AD) that
mirrors the natural onset and progression of the human disorder has been a
substantial barrier to basic and translational research into AD. Consequently, many�…
mirrors the natural onset and progression of the human disorder has been a
substantial barrier to basic and translational research into AD. Consequently, many�…
No less relevant results in the last month.