Most relevant results118 results in the last year.
APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease
This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer's
disease (AD) by examining its clinical, pathological and biomarker changes to see
whether APOE4 homozygotes constitute a distinct, genetically determined form of�…
disease (AD) by examining its clinical, pathological and biomarker changes to see
whether APOE4 homozygotes constitute a distinct, genetically determined form of�…
Genomic loci influence patterns of structural covariance in the human brain
Normal and pathologic neurobiological processes influence brain morphology in
coordinated ways that give rise to patterns of structural covariance (PSC) across
brain regions and individuals during brain aging and diseases. The genetic�…
coordinated ways that give rise to patterns of structural covariance (PSC) across
brain regions and individuals during brain aging and diseases. The genetic�…
Glutamine metabolism in diseases associated with mitochondrial dysfunction
Mitochondrial dysfunction can arise from genetic defects or environmental exposures
and impact a wide range of biological processes. Among these are metabolic
pathways involved in glutamine catabolism, anabolism, and glutamine-glutamate�…
and impact a wide range of biological processes. Among these are metabolic
pathways involved in glutamine catabolism, anabolism, and glutamine-glutamate�…
Gene-SGAN: discovering disease subtypes with imaging and genetic signatures via multi-view weakly-supervised deep clustering
Disease heterogeneity has been a critical challenge for precision diagnosis and
treatment, especially in neurologic and neuropsychiatric diseases. Many diseases
can display multiple distinct brain phenotypes across individuals, potentially�…
treatment, especially in neurologic and neuropsychiatric diseases. Many diseases
can display multiple distinct brain phenotypes across individuals, potentially�…
Exploring the Impact of Music on Response to Ketamine/Esketamine: A Scoping Review
Music and ketamine are both known to affect therapeutic outcomes, but few studies
have investigated their co-administration. This scoping review describes the existing
literature on the joint use of music and ketamine—or esketamine (the S (+)�…
have investigated their co-administration. This scoping review describes the existing
literature on the joint use of music and ketamine—or esketamine (the S (+)�…
Relationships of cognitive measures with cerebrospinal fluid but not imaging biomarkers of Alzheimer disease vary between Black and white individuals
Objective Biomarkers of Alzheimer disease vary between groups of self‐identified
Black and White individuals in some studies. This study examined whether the
relationships between biomarkers or between biomarkers and cognitive measures�…
Black and White individuals in some studies. This study examined whether the
relationships between biomarkers or between biomarkers and cognitive measures�…
Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer's disease
Breakdown of the neurovascular unit is associated with blood-brain barrier (BBB)
leakiness contributing to cognitive decline and disease pathology in the early stages
of Alzheimer's disease (AD). Vascular stability depends on angiopoietin-1 (ANGPT�…
leakiness contributing to cognitive decline and disease pathology in the early stages
of Alzheimer's disease (AD). Vascular stability depends on angiopoietin-1 (ANGPT�…
Four‐dimensional flow MRI for quantitative assessment of cerebrospinal fluid dynamics: Status and opportunities
Neurological disorders can manifest with altered neurofluid dynamics in different
compartments of the central nervous system. These include alterations in cerebral
blood flow, cerebrospinal fluid (CSF) flow, and tissue biomechanics. Noninvasive�…
compartments of the central nervous system. These include alterations in cerebral
blood flow, cerebrospinal fluid (CSF) flow, and tissue biomechanics. Noninvasive�…
Neuroimaging of tissue microstructure as a marker of neurodegeneration in the AT (N) framework: defining abnormal neurodegeneration and improving prediction of�…
Background Alzheimer's disease involves accumulating amyloid (A) and tau (T)
pathology, and progressive neurodegeneration (N), leading to the development of
the AD clinical syndrome. While several markers of N have been proposed, efforts to�…
pathology, and progressive neurodegeneration (N), leading to the development of
the AD clinical syndrome. While several markers of N have been proposed, efforts to�…
Peripheral macrophages drive CNS disease in the Ndufs4 (−/−) model of Leigh syndrome
Subacute necrotizing encephalopathy, or Leigh syndrome (LS), is the most common
pediatric presentation of genetic mitochondrial disease. LS is a multi‐system
disorder with severe neurologic, metabolic, and musculoskeletal symptoms. The�…
pediatric presentation of genetic mitochondrial disease. LS is a multi‐system
disorder with severe neurologic, metabolic, and musculoskeletal symptoms. The�…
No less relevant results in the last month.