Activin and inhibin are structurally related dimeric glycoproteins belonging to the
transforming growth factor-β superfamily of proteins which are synthesized and secreted by�…

Activin and inhibin are important local modulators of theca cell steroidogenesis in the ovary.
Using a serum-free primary theca cell culture system, this study investigated the effects of�…

OBJECTIVE: Our purpose was to determine the effects of transforming growth factor-β on
steroidogenesis and regulation of steroidogenic enzyme expression by use of a human�…

Abstract Effects of inhibin (recombinant human inhibin-A) on ovarian androgen synthesis
were tested in vitro using serum-free monolayer cultures of human thecal cells. Treatment for�…

The classic endocrine function of ovarian inhibin is negative feedback control of pituitary
FSH secretion (see de Jong, 1988 for a review). There is, however, a long-harboured�…

PROBLEM: Elevated serum inhibin levels have been found in ovarian cancer patients;
however, the source of the elevated inhibin is uncertain. Previous studies of activin in human�…

The gonadotropins, luteinizing hormone (LH) and folli cle-stimulating hormone (FSH), play
major roles in regulat ing the mammalian reproductive cycle by influencing the gametogenic�…

Recent reports suggest that activin (the dimer of inhibin β subunits with FSH-releasing
activity) has specific receptors on ovarian granulosa cells. The present study examined the�…

The physiological significance of these results will not become clear until patterns of activin
and inhibin protein production and the expression of their receptors have been more�…

Both experimental and clinical studies suggest that inhibin plays a critical role in the
development of granulosa cell tumors (GCT), a subgroup of malignant ovarian tumors�…