In 1992, nitric oxide (NO) was proclaimed the “molecule of the year” by Science magazine.
Despite the apparent plainness of this chemical that simply combines the chemical elements�…

The discovery of nitric oxide (NO) as an intercellular messenger or neurotransmitter opened
a new era for identifying the important mechanisms underlying physiological and�…

P lights of nitric oxide research in the penis. My sense of honor reflected an awareness of
the tremendous fortune I have had in being a major investigator of this exciting scientific�…

Penile erection is understood to be a neurally regulated physiologic event, although the
underlying mechanisms have eluded characterization for more than a century. The classical�…

It is widely accepted that nitric oxide plays an important role in the biology of the penis,
serving most familiarly as the agent responsible for penile erection. Early investigation in the�…

In recent years, a significant body of experimental evidence has accumulated implicating
nitric oxide as the central component of a novel signal transduction system that functions in�…

Purpose: The significance of nitric oxide in the physiology of the penis was evaluated,
including its role in pathophysiological mechanisms and pathological consequences�…

The functional state of the penis, flaccid or erect is governed by smooth muscle tone.
Sympathetic contractile factors maintain flaccidity whilst parasympathetic factors induce�…

Nitric oxide is a gaseous molecule with toxic properties, but it is also a biologically active
substance involved in numerous physiologic processes. In recent years, this obscure�…

The role of nitric oxide as a modulator of penile erection has recently been the subject of
extensive investigation. Nitric oxide is synthesized by both the endothelium lining the�…