Abstract Intracellular phosphoinositide 3-kinase (PI3K) signaling is activated by multiple
bone-active receptors. Genetic mutations activating PI3K signaling are associated with�…

Studies on bone development, formation and turnover have grown exponentially over the
last decade in part because of the utility of genetic models. One area that has received�…

Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) is a lipid kinase that
plays a pivotal role in the regulation of receptor-mediated calcium signaling in multiple�…

Type 1 phosphotidylinosotol-4 phosphate 5 kinase γ (PIP5KIγ) is central to generation of
phosphotidylinosotol (4, 5) P 2 (PI (4, 5) P 2). PIP5KIγ also participates in cytoskeletal�…

To study the role of the Pten tumor suppressor in skeletogenesis, we generated mice lacking
this key phosphatidylinositol 3′‐kinase pathway regulator in their osteo�…

Phosphatidylinositol 3-kinases (PI3K) participate in numerous signaling pathways, and
control distinct biological functions. Studies using pan-PI3K inhibitors suggest roles for PI3K�…

Bone development and remodeling are controlled by the phosphoinositide-3-kinase (Pi3k)
signaling pathway. We investigated the effects of downregulation of phosphatase and tensin�…

Phosphatidylinositol-3-kinases (PI3-Ks) play an important role in signal transduction and
have been implicated in mediating a broad range of cellular responses. There are three�…

The phosphoinositide 3-kinase and AKT (protein kinase B) signaling pathway (PI3K/AKT)
plays a central role in the control of cell survival, growth, and proliferation throughout the�…

Bone formation is carried out by the osteoblast, a mesenchymal cell whose lifespan and
activity are regulated by growth factor signaling networks. Growth factors activate�…