User profiles for Yongde Luo
 | Yongde LuoProfessor of Wenzhou Medical University Verified email at wmu.edu.cn Cited by 3523 |
[HTML][HTML] The significance of mitochondrial dysfunction in cancer
As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in
energy metabolism, maintenance of redox balance, and regulation of apoptosis. Mitochondrial …
energy metabolism, maintenance of redox balance, and regulation of apoptosis. Mitochondrial …
[HTML][HTML] The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
FGF21 is a multifunctional metabolic regulator. The co-factor βKlotho (KLB) allows FGF21 to
signal via FGF receptors. Given the widespread nature of FGFR expression and KLB …
signal via FGF receptors. Given the widespread nature of FGFR expression and KLB …
[HTML][HTML] Fibroblast growth factor-10: a second candidate stromal to epithelial cell andromedin in prostate
Fibroblast growth factor (FGF)-10, a homologue of FGF-7, is expressed significantly in normal
rat prostate tissue, well differentiated rat prostate tumors with an epithelial and stromal …
rat prostate tissue, well differentiated rat prostate tumors with an epithelial and stromal …
[HTML][HTML] Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB
Background Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21
redirect FGFR signaling to regulation of metabolic homeostasis and suppression of obesity …
redirect FGFR signaling to regulation of metabolic homeostasis and suppression of obesity …
Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex
Fibroblast growth factor 21 (FGF21) is a distinctive member of the FGF family with potent
beneficial effects on lipid, body weight, and glucose metabolism and has attracted considerable …
beneficial effects on lipid, body weight, and glucose metabolism and has attracted considerable …
[HTML][HTML] Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy
Elevated aerobic glycolysis in cancer cells (the Warburg effect) may be attributed to respiration
injury or mitochondrial dysfunction, but the underlying mechanisms and therapeutic …
injury or mitochondrial dysfunction, but the underlying mechanisms and therapeutic …
Oncogenic KRAS reduces expression of FGF21 in acinar cells to promote pancreatic tumorigenesis in mice on a high-fat diet
… Yongde Luo, Yaying Yang, and Muyun Liu performed the experiments and drafted the
manuscript. Yongde Luo also conceived and designed the experiments and contributed reagents. …
manuscript. Yongde Luo also conceived and designed the experiments and contributed reagents. …
Structural Basis for Interaction of FGF-1, FGF-2, and FGF-7 with Different Heparan Sulfate Motifs,
Stromal cell-derived FGF-7 binds and activates only the resident FGFR2IIIb in epithelial cells
while FGF-1 and FGF-2 exhibit a broader interaction with multiple isoforms of FGFR. Here …
while FGF-1 and FGF-2 exhibit a broader interaction with multiple isoforms of FGFR. Here …
[HTML][HTML] Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress
Background FGF21 is a promising intervention therapy for metabolic diseases as fatty liver,
obesity and diabetes. Recent results suggest that FGF21 is highly expressed in hepatocytes …
obesity and diabetes. Recent results suggest that FGF21 is highly expressed in hepatocytes …
FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet–Induced fatty liver
OBJECTIVE—Fibroblast growth factor (FGF) family signaling largely controls cellular
homeostasis through short-range intercell paracrine communication. Recently FGF15/19, 21, and …
homeostasis through short-range intercell paracrine communication. Recently FGF15/19, 21, and …