Steroid receptors and coactivator proteins are thought to stimulate gene expression by
facilitating the assembly of basal transcription factors into a stable preinitiation complex 1 . What …

Establishment and maintenance of pregnancy results from signaling by the conceptus (embryo/fetus
and associated extraembryonic membranes) and requires progesterone produced …

Implantation in all mammals involves shedding of the zona pellucida, followed by orientation,
apposition, attachment and adhesion of the blastocyst to the endometrium. Endometrial …

Progesterone is unequivocally required for maternal support of conceptus (embryo/fetus
and associated extraembryonic membranes) survival and development. In cyclic sheep, …

l-Arginine (Arg) is synthesised from glutamine, glutamate, and proline via the intestinal-renal
axis in humans and most other mammals (including pigs, sheep and rats). Arg degradation …

Nutrition is the major intrauterine environmental factor that alters expression of the fetal
genome and may have lifelong consequences. This phenomenon, termed “fetal programming,” …

Osteopontin (OPN) is an acidic member of the small integrin-binding ligand N-linked
glycoprotein (SIBLING) family of extracellular matrix proteins/cytokines that undergoes extensive …

Mechanisms regulating responses of the ovine uterus to endocrine and paracrine signals
during the estrous cycle and pregnancy are likely to require tissue- and cell-specific regulation …

The placenta is the organ that transports nutrients, respiratory gases, and wastes between
the maternal and fetal systems. Consequently, placental blood flow and vascular …

The present review highlights new information on pregnancy recognition and conceptus
development and implantation in sheep with respect to regulation by progesterone, interferons …