Background The efficacy of thiazolidinediones, as compared with other oral glucose-lowering
medications, in maintaining long-term glycemic control in type 2 diabetes is not known. …

Obesity is associated with an increased risk of developing insulin resistance and type 2
diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified fatty …

To determine the relationship between insulin sensitivity and β-cell function, we quantified the
insulin sensitivity index using the minimal model in 93 relatively young, apparently healthy …

… *Address all correspondence and requests for reprints to: Steven E. Kahn MB, Ch.B.,
Veterans Affairs Puget Sound Health Care System (151), 1660 South Columbian Way, Seattle, …

Objective: This report examines what is known about the relationship between obesity and
type 2 diabetes and how future research in these areas might be directed to benefit prevention…

Glucose metabolism is normally regulated by a feedback loop including islet β cells and
insulin-sensitive tissues, in which tissue sensitivity to insulin affects magnitude of β-cell response…

… Address correspondence and reprint requests to Steven E. Kahn, MB, ChB, VA Medical
Center (151), 1660 South Columbian Way, Seattle WA 98108. Received for publication 29 …

Context: Insulin resistance is an almost universal finding in nonalcoholic fatty liver disease (NAFLD).
This review outlines the evidence linking insulin resistance and NAFLD, explores …

Background Semaglutide, a glucagon-like peptide-1 receptor agonist, has been shown to
reduce the risk of adverse cardiovascular events in patients with diabetes. Whether …

OBJECTIVE—The purpose of this study was to examine possible factors associated with the
increased risk of fractures observed with rosiglitazone in A Diabetes Outcome Progression …