Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis
NJ Sarma, V Tiriveedhi, JS Crippin…�- …�of virology, 2014 - Am Soc Microbiol
Hepatitis C virus (HCV)-mediated liver diseases are one of the major health issues in the
United States and worldwide. HCV infection has been reported to modulate microRNAs
(miRNAs) that control various cell surface receptors and gene-regulatory complexes
involved in hepatic inflammation and liver diseases. We report here that specific
downregulation of miRNA-107 and miRNA-449a following HCV infection in patients with
HCV-mediated liver diseases modulates expression of CCL2, an inflammatory chemokine�…
United States and worldwide. HCV infection has been reported to modulate microRNAs
(miRNAs) that control various cell surface receptors and gene-regulatory complexes
involved in hepatic inflammation and liver diseases. We report here that specific
downregulation of miRNA-107 and miRNA-449a following HCV infection in patients with
HCV-mediated liver diseases modulates expression of CCL2, an inflammatory chemokine�…
1030-LBP: Hepatitis C virus induced changes in microRNA-107 and microRNA-449a modulate the inflammatory chemokine CCL2 by targeting IL6 receptor complex�…
Aim Hepatitis C virus (HCV) mediated liver diseases are one of the major health issues in
United States and worldwide. This study is to identify the role of HCV induced changes in
microRNAs (miRNA) that controls various cell surface receptors and gene regulatory
complexes involved in patients with HCV mediated inflammation and fibrosis. Methods
Computational sequence analyses and reporter assays using the CCL2 promoter region
were carried out to analyze transcription factors. Gene expression analyses were done�…
United States and worldwide. This study is to identify the role of HCV induced changes in
microRNAs (miRNA) that controls various cell surface receptors and gene regulatory
complexes involved in patients with HCV mediated inflammation and fibrosis. Methods
Computational sequence analyses and reporter assays using the CCL2 promoter region
were carried out to analyze transcription factors. Gene expression analyses were done�…
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