<p>Whole-body glucose homeostasis is coordinated through secretion of glucagon and
insulin from pancreatic islets. When glucose is low, glucagon is released from α-cells to …

Since the discovery of glucagon 100 years ago, the hormone, and the pancreatic islet alpha
cells that produce it, have remained enigmatic relative to insulin producing beta cells. …

Objectives Elevated plasma glucagon is an early symptom of diabetes, occurring in subjects
with impaired glucose regulation. Here, we explored alpha-cell function in female mice fed …

Context Although diabetes affects 40% to 50% of adults with cystic fibrosis, remarkably little
is known regarding the underlying mechanisms leading to impaired pancreatic β-cell insulin …

Diabetes is defined by hyperglycaemia due to progressive insulin resistance and compromised
insulin release. In parallel, alpha cells develop dysregulation of glucagon secretion. …

β-Cell dysfunction in type 2 diabetes (T2D) is associated with loss of cellular identity and mis-expression
of alternative islet hormones, including glucagon. The molecular basis for these …

Purpose To characterize the effects of fat on commonly used T 1 mapping sequences and
evaluate a new method of quantitative fat fraction (FF) imaging for low fractions based on the …

… In two recently published essays (based on her Harvard dissertation), Sarah Sentilles attends
to the place of theological discourse and rhetoric in the work of Roland Barthes and Susan …

The relative contribution of pancreatic beta cell dysfunction and cell death to the decline in
insulin production in type 2 diabetes (T2D) is debated. Although, undoubtedly, some cell …

Those of us who ttade in contemporary French philosophy are supposed to be able, at the
drop of a hat, to tick off the various symptoms of modernism's demise: the death of the subject, …