Amyloid deposition and reduced β-cell mass are pathological hallmarks of the pancreatic
islet in type 2 diabetes; however, whether the extent of amyloid deposition is associated with …

Type 2 diabetes is a progressive disease characterised by islet amyloid deposits in the
majority of patients. Amyloid formation is considered a significant factor in deterioration of islet …

Neprilysin is a widely expressed peptidase with broad substrate specificity that preferentially
hydrolyses oligopeptide substrates, many of which regulate the cardiovascular, nervous …

Impaired fasting glucose (IFG) is more prevalent in men and impaired glucose tolerance (IGT)
more prevalent in women. To explore whether this sex difference is related to female sex …

The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to
the islet β cell. Impairments in propeptide processing and secretory function, along with the …

Context: Although obesity has been, in general, associated with glomerular hyperfiltration,
visceral adiposity has been suggested to be associated with reduced glomerular filtration. …

Islet amyloid deposition in type 2 diabetes is associated with reduced β-cell mass. Therefore,
interventions aimed at reducing islet amyloid formation may help preserve β-cell mass in …

Aims/hypothesis Amyloid deposition and inflammation are characteristic of islet pathology in
type 2 diabetes. The aim of this study was to determine whether islet amyloid formation is …

Mouse models are widely used for elucidating mechanisms underlying type 2 diabetes. Genetic
background profoundly affects metabolic phenotype; therefore selecting the appropriate …

Aim/hypothesis Neprilysin, a widely expressed peptidase, is upregulated in metabolically
altered states such as obesity and type 2 diabetes. Like dipeptidyl peptidase-4 (DPP-4), …