Does childhood trauma moderate polygenic risk for depression? A meta-analysis of 5765 subjects from the psychiatric genomics consortium
Background The heterogeneity of genetic effects on major depressive disorder (MDD) may
be partly attributable to moderation of genetic effects by environment, such as exposure to
childhood trauma (CT). Indeed, previous findings in two independent cohorts showed
evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing
directions. This study aims to meta-analyze MDD-PRS� CT interaction results across these
two and other cohorts, while applying more accurate PRSs based on a larger discovery�…
be partly attributable to moderation of genetic effects by environment, such as exposure to
childhood trauma (CT). Indeed, previous findings in two independent cohorts showed
evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing
directions. This study aims to meta-analyze MDD-PRS� CT interaction results across these
two and other cohorts, while applying more accurate PRSs based on a larger discovery�…
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