Baicalin ameliorates hepatic insulin resistance and gluconeogenic activity through inhibition of p38 MAPK/PGC-1α pathway

P Fang, Y Sun, X Gu, M Shi, P Bo, Z Zhang, L Bu�- Phytomedicine, 2019 - Elsevier
Background Although the results of our and other studies show that baicalin can enhance
glucose uptake and insulin sensitivity in skeletal muscle and adipocytes of mice, the specific …

Adipose–Muscle crosstalk in age-related metabolic disorders: The emerging roles of adipo-myokines

P Fang, Y She, M Yu, W Min, W Shang…�- Ageing Research Reviews, 2023 - Elsevier
Obesity and type 2 diabetes account for a considerable proportion of the global burden of
age-related metabolic diseases. In age-related metabolic diseases, tissue crosstalk and …

Baicalin and its aglycone: a novel approach for treatment of metabolic disorders

P Fang, M Yu, M Shi, P Bo, X Gu, Z Zhang�- Pharmacological Reports, 2020 - Springer
Background The current strategies for prevention and treatment of insulin resistance and
type 2 diabetes are not fully effective and frequently accompanied by many negative effects. …

Galanin and its receptors: a novel strategy for appetite control and obesity therapy

P Fang, M Yu, L Guo, P Bo, Z Zhang, M Shi�- Peptides, 2012 - Elsevier
The rapid increase in the prevalence of overweight and obesity is becoming an important
health problem. Overweight and obesity may cause several metabolic complications, including …

[HTML][HTML] Treatment with celastrol protects against obesity through suppression of galanin-induced fat intake and activation of PGC-1α/GLUT4 axis-mediated glucose�…

P Fang, B He, M Yu, M Shi, Y Zhu, Z Zhang…�- Biochimica et Biophysica�…, 2019 - Elsevier
Overweight and obesity may cause several metabolic complications, including type 2 diabetes
mellitus and hyperlipidemia. Despite years of progress in medicine, there are no highly …

Baicalin against obesity and insulin resistance through activation of AKT/AS160/GLUT4 pathway

P Fang, M Yu, L Zhang, D Wan, M Shi, Y Zhu…�- Molecular and cellular�…, 2017 - Elsevier
Obesity may cause several metabolic complications, including insulin resistance and type 2
diabetes mellitus. Despite great advances in medicine, people still keep exploring novel and …

Beneficial effect of galanin on insulin sensitivity in muscle of type 2 diabetic rats

…, L Zhang, G Li, L Zhang, H Shao, J Li, P Fang…�- Physiology &�…, 2011 - Elsevier
The aim of this study was to determine whether enhanced galanin (GAL) release induced by
exercise would elevate insulin sensitivity and glucose transporter 4 (GLUT4) concentration …

Beneficial effect of baicalin on insulin sensitivity in adipocytes of diet-induced obese mice

P Fang, M Yu, W Min, S Han, M Shi, Z Zhang…�- Diabetes research and�…, 2018 - Elsevier
Aims Although baicalin has been shown to increase glucose uptake and insulin sensitivity in
skeletal muscle of mice, there is no literature available about the effect of baicalin on insulin …

Type 2 diabetes mellitus as a disorder of galanin resistance

P Fang, M Shi, Y Zhu, P Bo, Z Zhang�- Experimental gerontology, 2016 - Elsevier
The increasing prevalence of type 2 diabetes mellitus with its high morbidity and mortality
becomes an important health problem. The multifactorial etiology of type 2 diabetes mellitus is …

Galanin peptide family as a modulating target for contribution to metabolic syndrome

P Fang, M Yu, M Shi, Z Zhang, Y Sui, L Guo…�- General and comparative�…, 2012 - Elsevier
Metabolic syndrome (MetS) is defined as abdominal central obesity, atherogenic
dyslipidemia, insulin resistance, glucose intolerance and hypertension. The rapid increasing …