Naltrexone, an opiate antagonist, had both stimulatory and inhibitory effects, depending on
the dosage, on the growth of S20Y neuroblastoma in A/Jax mice. Daily injections of 0.1 …

Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition
to serving for neurotransmission/neuromodulation in the nervous system. The native opioid …

From birth to day 21, rat offspring received daily injections of naltrexone at a dosage that
blocked morphine-induced analgesia 24 hours a day. At 21 days, body, brain, and cerebellar …

Endogenous opioid systems (ie opioids and opioid receptors) play a role in regulating neural
development. Using the cerebellar cortex of 6-day-old rats, the most potent opioid peptides …

Objective To determine whether topical application of insulin normalizes delayed corneal
wound healing in rats with diabetes mellitus (DB). Methods Diabetes mellitus was induced with …

Opioid growth factor (OGF) is an endogenous opioid peptide ([Met 5 ]enkephalin) that interacts
with the OGF receptor (OGFr) and serves as a tonically active negative growth factor in …

purpose. To determine the influence of endogenous opioid modulation on reepithelialization
of the human cornea. methods. Eight-millimeter-diameter epithelial defects were created …

This study was designed to examine the role of opioids in cell survival, with an emphasis on
the mechanism of opioid growth factor (OGF, [Met 5 ]-enkephalin)-dependent growth …

Squamous cell carcinoma of the head and neck (SCCHN) is the sixth most common malignancy
worldwide. Approximately half of the patients afflicted die within 5 years of diagnosis, …

The opioid growth factor (OGF) regulates cell proliferation of human cancer cells through
the cyclin-dependent kinase inhibitory pathway, with mediation of this action by the OGF …