Haptoglobin serves as an antioxidant by virtue of its ability to prevent hemoglobin-driven
oxidative tissue damage. It was recently demonstrated that an allelic polymorphism in the …

Haptoglobin is an abundant hemoglobin-binding protein present in the plasma. The function
of haptoglobin is primarily to determine the fate of hemoglobin released from red blood cells …

A major function of haptoglobin (Hp) is to bind hemoglobin (Hb) to form a stable Hp-Hb
complex and thereby prevent Hb-induced oxidative tissue damage. Clearance of the Hp-Hb …

Recent insights into IQSEC2 disease are summarized in this review as follows: (1) Exome
sequencing of IQSEC2 patient DNA has led to the identification of numerous missense …

The blind subterranean mole rat superspecies Spalax ehrenbergi has evolved adaptations
that allow it to survive and carry out intensive activities in its highly hypoxic underground …

Background Whereas there exists a direct relationship between glycated hemoglobin and
cardiovascular disease (CVD), clinical trials targeting glycated hemoglobin to near-normal …

OBJECTIVE Intensive glycemic therapy reduced coronary artery disease (CAD) events
among White participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) …

Mutations in IQSEC2 cause intellectual disability (ID), which is often accompanied by
seizures and autism. A number of studies have shown that IQSEC2 is an abundant protein in …

Background Coronary artery disease has been linked with genotypes for haptoglobin (Hp)
which modulates extracorpuscular hemoglobin. We hypothesized that the Hp genotype would …

Background The Hp (haptoglobin)2‐2 phenotype (~40% of people) is associated with
dysfunctional high‐density lipoprotein (HDL) that is heavily oxidized in hyperglycemia, which may …