Vascular endothelial growth factor (VEGF), a potent angiogenic factor and endothelial cell-specific
mitogen, is up-regulated by hypoxia. However, the mechanism(s) responsible for …

The major control point for the hypoxic induction of the vascular endothelial growth factor (VEGF)
gene is the regulation of the steady-state level of the mRNA. We previously …

Vascular endothelial growth factor (VEGF) is a potent angiogenic factor whose expression is
dramatically induced by hypoxia due in large part to an increase in the stability of its mRNA. …

Haptoglobin serves as an antioxidant by virtue of its ability to prevent hemoglobin-driven
oxidative tissue damage. It was recently demonstrated that an allelic polymorphism in the …

Collateral blood vessels supplement normal coronary blood flow and coronary blood flow
compromised by coronary artery disease, thereby protecting the myocardium from ischemia. …

Haptoglobin is an abundant hemoglobin-binding protein present in the plasma. The function
of haptoglobin is primarily to determine the fate of hemoglobin released from red blood cells …

A major function of haptoglobin (Hp) is to bind hemoglobin (Hb) to form a stable Hp-Hb
complex and thereby prevent Hb-induced oxidative tissue damage. Clearance of the Hp-Hb …

Hypoxia induces an increase in the stability of the mRNA encoding vascular endothelial
growth factor (VEGF). We have previously demonstrated that a 500-base region of the 3′-…

… Dr Andrew Levy dedicates this manuscript to the memory of his sister Dr Joanne Levy, a
caring physician and brilliant scientist. Joanne was responsible for developing the strategy for …

Patients with diabetes presenting with acute myocardial infarction (AMI) have an increased
rate of death and heart failure. Patients with diabetes homozygous for the haptoglobin (Hp) 1 …