It is recognized that a chronic low-grade inflammation and an activation of the immune system
are involved in the pathogenesis of obesity-related insulin resistance and type 2 diabetes. …

Aims/hypothesis Obesity is a heterogeneous condition comprising both individuals who
remain metabolically healthy (MHO) and those who develop metabolic disorders (metabolically …

Obesity and insulin resistance are associated with the development of type 2 diabetes. It is
well accepted that beta cell dysfunction is required for hyperglycaemia to occur. The …

Introduction: There is a growing body of evidence to suggest that chronic silent inflammation
is a key feature in abdominal obesity, metabolic syndrome, type 2 diabetes (T2DM) and …

Objectives: A growing body of evidence emerges that obesity, metabolic syndrome, type 2
diabetes and cardiovascular disease are intimately related to chronic inflammation. Methods: …

Free fatty acids (FFAs) are metabolic intermediates that may be obtained through the diet or
synthesized endogenously. In addition to serving as an important source of energy, they …

A growing body of evidence is emerging to show that abdominal obesity, the metabolic
syndrome, type 2 diabetes, cardiovascular disease and microvascular diabetic complications are …

The NLRP3 inflammasome is involved in many obesity-associated diseases, such as type 2
diabetes, atherosclerosis, and gouty arthritis, through its ability to induce interleukin (IL)-1β …

Neprilysin is a widely expressed peptidase with broad substrate specificity that preferentially
hydrolyses oligopeptide substrates, many of which regulate the cardiovascular, nervous …

Objective To determine if serum amyloid A (A-SAA) could be detected in human osteoarthritic
(OA) joints and further clarify if high A-SAA level in joints result from a local production or …