More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

Skeletal muscle extracts glucose from the blood to maintain demand for carbohydrates as
an energy source during exercise. Such uptake involves complex molecular signalling …

Exercise is essential in regulating energy metabolism and whole-body insulin sensitivity. To
explore the exercise signaling network, we undertook a global analysis of protein …

Objective The growth differentiation factor 15 (GDF15) is a stress-sensitive circulating factor
that regulates systemic energy balance. Since exercise is a transient physiological stress …

Uncertainty exists as to whether the glucose-dependent insulinotropic polypeptide receptor (GIPR)
should be activated or inhibited for the treatment of obesity. Gipr was recently …

The actin cytoskeleton–regulating GTPase Rac1 is required for insulin-stimulated GLUT4
translocation in cultured muscle cells. However, involvement of Rac1 and its downstream …

Glucagon and thyroid hormone (T 3 ) exhibit therapeutic potential for metabolic disease but
also exhibit undesired effects. We achieved synergistic effects of these two hormones and …

Insulin resistance is a major health risk, and although exercise clearly improves skeletal
muscle insulin sensitivity, the mechanisms are unclear. Here we show that initiation of a …

Growth differentiation factor 15 (GDF15) is a cytokine best known for affecting systemic energy
metabolism through its anorectic action. GDF15 expression and secretion from various …

Skeletal muscle plays a major role in regulating whole body glucose metabolism. Akt and
Rac1 are important regulators of insulin-stimulated glucose uptake in skeletal muscle. …