Increased macroautophagy/autophagy and lysosomal activity promote tumor growth, survival
and chemo-resistance. During acute starvation, autophagy is rapidly engaged by AMPK (…

TOR (target of rapamycin), an evolutionarily-conserved serine/threonine kinase, acts as a
central regulator of cell growth, proliferation and survival in response to nutritional status, …

TFEB and TFE3 are transcriptional regulators of the innate immune response, but the
mechanisms regulating their activation upon pathogen infection are poorly elucidated. Using C. …

Growing tumors exist in metabolically compromised environments that require activation of
multiple pathways to scavenge nutrients to support accelerated rates of growth. The folliculin (…

Non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide and
can progress to non-alcoholic steatohepatitis (NASH), which is characterized by triglyceride …

The fact that some organisms are able to regenerate organs of the correct shape and size
following amputation is particularly fascinating, but the mechanism by which this occurs …

The skeletal muscle ATP-sensitive K + (K ATP ) channel is crucial in preventing fiber damage
and contractile dysfunction, possibly by preventing damaging ATP depletion. The objective …

… Abstract: We show using string dualities that Mathieu moonshine controls GromovWitten
invariants and periods of the holomorphic 3-form Ω for certain CY3 manifolds. We also discuss …

Autophagy is a cellular process where redundant, damaged, or mislocalized molecules are
recycled to create energy and to provide building blocks for protein synthesis. It is an …

The aesthetic quality of the dodecahedron, the largest of the convex polyhedra once believed
to constitute the building block of heavenly matter, was fully appreciated in ancient times. …