TOR (target of rapamycin), an evolutionarily-conserved serine/threonine kinase, acts as a
central regulator of cell growth, proliferation and survival in response to nutritional status, …

TFEB and TFE3 are transcriptional regulators of the innate immune response, but the
mechanisms regulating their activation upon pathogen infection are poorly elucidated. Using C. …

Growing tumors exist in metabolically compromised environments that require activation of
multiple pathways to scavenge nutrients to support accelerated rates of growth. The folliculin (…

Increased macroautophagy/autophagy and lysosomal activity promote tumor growth, survival
and chemo-resistance. During acute starvation, autophagy is rapidly engaged by AMPK (…

Transmembrane glycoprotein NMB (GPNMB) is a prognostic marker of poor outcome in
patients with triple-negative breast cancer (TNBC). Glembatumumab Vedotin, an antibody drug …

A biomarker is a qualitative and quantitative biological substance or characteristic that defines
a certain pathological condition and may give indications on disease severity and the type …

The FLCN tumor suppressor complex (FLCN, FNIP1, FNIP2) has been implicated in the
regulation of energy homeostasis via two metabolic master kinases: AMPK and mTORC1. These …

Despite recent advances in chemotherapy, aggressive and metastatic breast cancers
remain refractory to targeted therapy and the development of novel drugs is urgently needed. …

Acute myeloid leukemia (AML) is one of the most frequent types of blood malignancies. It is
a complex disorder of undifferentiated hematopoietic progenitor cells. The majority of …

Non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide and
can progress to non-alcoholic steatohepatitis (NASH), which is characterized by triglyceride …