Glucocorticoid and mineralocorticoid receptors in the brain: a transcriptional perspective

ASCAM Koning, JC Buurstede…�- Journal of the�…, 2019 - academic.oup.com
Adrenal glucocorticoid hormones are crucial for maintenance of homeostasis and adaptation
to stress. They act via the mineralocorticoid receptors (MRs) and glucocorticoid receptors (…

[HTML][HTML] Corticosteroid action in the brain: the potential of selective receptor modulation

EMG Viho, JC Buurstede, A Mahfouz, LL Koorneef…�- …, 2019 - karger.com
Glucocorticoid hormones have important effects on brain function in the context of acute and
chronic stress. Many of these are mediated by the glucocorticoid receptor (GR). GR has …

An emerging role for microglia in stress‐effects on memory

J Sanguino‐G�mez, JC Buurstede…�- European Journal of�…, 2022 - Wiley Online Library
Stressful experiences evoke, among others, a rapid increase in brain (nor)epinephrine (NE)
levels and a slower increase in glucocorticoid hormones (GCs) in the brain. Microglia are …

Hippocampal glucocorticoid target genes associated with enhancement of memory consolidation

JC Buurstede, LTCM van Weert…�- European Journal of�…, 2022 - Wiley Online Library
Glucocorticoids enhance memory consolidation of emotionally arousing events via largely
unknown molecular mechanisms. This glucocorticoid effect on the consolidation process also …

NeuroD factors discriminate mineralocorticoid from glucocorticoid receptor DNA binding in the male rat brain

LTCM van Weert, JC Buurstede, A Mahfouz…�- …, 2017 - academic.oup.com
In the limbic brain, mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) both
function as receptors for the naturally occurring glucocorticoids (corticosterone/cortisol) but …

Cell type specificity of glucocorticoid signaling in the adult mouse hippocampus

EMG Viho, JC Buurstede, JB Berkhout…�- Journal of�…, 2022 - Wiley Online Library
Glucocorticoid stress hormones are powerful modulators of brain function and can affect
mood and cognitive processes. The hippocampus is a prominent glucocorticoid target and …

[HTML][HTML] Androgens modulate glucocorticoid receptor activity in adipose tissue and liver

…, M Nixon, JC Buurstede…�- Journal of�…, 2019 - joe.bioscientifica.com
Glucocorticoid signaling is context dependent, and in certain scenarios, glucocorticoid
receptors (GRs) are able to engage with other members of the nuclear receptor subfamily. …

[HTML][HTML] Application of a pharmacological transcriptome filter identifies a shortlist of mouse glucocorticoid receptor target genes associated with memory consolidation

JC Buurstede, EHL Umeoka, MS da Silva…�- …, 2022 - Elsevier
Glucocorticoids regulate memory consolidation, facilitating long-term storage of relevant
information to adequately respond to future stressors in similar conditions. This effect of …

Transcriptional glucocorticoid effects in the brain: Finding the relevant target genes

OC Meijer, JC Buurstede, EMG Viho…�- Journal of�…, 2023 - Wiley Online Library
Glucocorticoids are powerful modulators of brain function. They act via mineralocorticoid and
glucocorticoid receptors (MR and GR). These are best understood as transcription factors. …

Identification of mineralocorticoid receptor target genes in the mouse hippocampus

LTCM van Weert, JC Buurstede…�- Journal of�…, 2019 - Wiley Online Library
Brain mineralocorticoid receptors ( MR s) and glucocorticoid receptors ( GR s) respond to the
same glucocorticoid hormones but can have differential effects on cellular function. Several …