We identified a gene in the ovine hypothalamus encoding for RFamide-related peptide-3 (RFRP-3),
and tested the hypothesis that this system produces a hypophysiotropic hormone …

The KiSS-1 gene encodes a family of peptides called kisspeptins, which are endogenous
ligands for the G protein-coupled receptor GPR54. Kisspeptin function appears to be critical for …

Hypothalamo-hypophyseal portal blood has been collected from conscious OVX ewes by a
procedure that permits maintenance of pituitary function. GnRH was measured in portal …

Kisspeptin is a potent stimulator of GnRH secretion that has been implicated in the feedback
actions of ovarian steroids. In ewes, the majority of hypothalamic kisspeptin neurons are …

Kisspeptins are the product of the Kiss1 gene and potently stimulate GnRH secretion. In
sheep, Kiss1 mRNA-expressing cells are found in the arcuate nucleus (ARC) and dorsal-lateral …

The means by which stress influences reproduction is not clearly understood, but may involve
a number of endocrine, paracrine and neural systems. Stress impacts on the reproductive …

Gonadotropin releasing hormone (GnRH) secretion represents the final common pathway
in the control of the reproductive axis. Dogma has been that GnRH is solely responsible for …

Objective: Gonadotropin-inhibitory hormone (GnIH)-3 is a neuropeptide that plays a major
role in the regulation of reproduction and feeding in mammals. Materials and Methods: We …

Neurons that produce gonadotropin-releasing hormone (GnRH) are the final common pathway
by which the brain regulates reproduction. GnRH neurons are regulated by an afferent …

Reproductive activity in sheep is seasonal, being activated by short-day photoperiods and
inhibited by long days. During the nonbreeding season, GnRH secretion is reduced by both …