Glucocorticoid signaling is context dependent, and in certain scenarios, glucocorticoid
receptors (GRs) are able to engage with other members of the nuclear receptor subfamily. …

Objective Brown adipose tissue (BAT) displays a strong circadian rhythm in metabolic
activity, but it is unclear how this rhythm is regulated. As circulating levels of corticosterone …

Disruption of circadian rhythmicity is associated with obesity and related disorders, including
type 2 diabetes and cardiovascular disease. Specifically, prolonged artificial light exposure …

The endocannabinoid system is an important player in energy metabolism by regulating
appetite, lipolysis, and energy expenditure. Chronic blockade of the cannabinoid 1 receptor (…

In the limbic brain, mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) both
function as receptors for the naturally occurring glucocorticoids (corticosterone/cortisol) but …

Steroid receptors are pleiotropic transcription factors that coordinate adaptation to different
physiological states. An important target organ is the brain, but even though their effects are …

Medication for nonalcoholic fatty liver disease (NAFLD) is an unmet need. Glucocorticoid (GC)
stress hormones drive fat metabolism in the liver, but both full blockade and full …

… Hetty CM Sips , Hetty CM Sips … Jan Kroon, Lisa L Koorneef, Jose K van den Heuvel,
Cristy RC Verzijl, Nienke M van de Velde, Isabel M Mol, Hetty CM Sips, Hazel Hunt, Patrick CN …

Brain mineralocorticoid receptors ( MR s) and glucocorticoid receptors ( GR s) respond to the
same glucocorticoid hormones but can have differential effects on cellular function. Several …

Objective Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows
diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking around …