Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate hunger. Agouti-related
protein (AgRP) neurons in the ARC (ARC AgRP neurons) are stimulated by fasting and…

Pro-opiomelanocortin (POMC)-expressing neurons in the arcuate nucleus of the hypothalamus
represent key regulators of metabolic homeostasis. Electrophysiological and single-cell …

Sensory neurons relay gut-derived signals to the brain, yet the molecular and functional
organization of distinct populations remains unclear. Here, we employed intersectional genetic …

The hypothalamic arcuate–median eminence complex (Arc-ME) controls energy balance,
fertility and growth through molecularly distinct cell types, many of which remain unknown. To …

Activation of Agouti-Related Peptide (AgRP)-expressing neurons promotes feeding and
insulin resistance. Here, we examine the contribution of neuropeptide Y (NPY)-dependent …

Systemic metabolism has to be constantly adjusted to the variance of food intake and even
be prepared for anticipated changes in nutrient availability. Therefore, the brain integrates …

The hypothalamus plays a key role in coordinating fundamental body functions. Despite
recent progress in single-cell technologies, a unified catalog and molecular characterization of …

Physiological needs bias perception and attention to relevant sensory cues. This process is ‘hijacked’
by drug addiction, causing cue-induced cravings and relapse. Similarly, its …

‘Sundowning’ in dementia and Alzheimer’s disease is characterized by early-evening agitation
and aggression. While such periodicity suggests a circadian origin, whether the circadian …

The needs of the body can direct behavioral and neural processing toward motivationally
relevant sensory cues. For example, human imaging studies have consistently found specific …