Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …

Many lines of evidence, including epidemiologic data and extensive clinical and experimental
studies, indicate that early life events play a powerful role in influencing later susceptibility …

Fetal growth is determined by the interaction between the environment and the fetal genome.
The fetal environment, in turn, is determined by the maternal environment and by maternal …

The lyso-phospholipid sphingosine 1-phosphate modulates lymphocyte trafficking, endothelial
development and integrity, heart rate, and vascular tone and maturation by activating G …

The role of cholesterol in eukaryotic membrane protein function has been attributed primarily
to an influence on membrane fluidity and curvature. We present the 2.8 � resolution crystal …

Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors constitute
the largest family of eukaryotic signal transduction proteins that communicate across the …

Metabolic syndrome (MetS) represents a combination of cardio-metabolic risk determinants,
including central obesity, insulin resistance, glucose intolerance, dyslipidemia, hypertension…

Epidemiological observations have led to the hypothesis that the risk of developing some
chronic noncommunicable diseases in adulthood is influenced not only by genetic and adult …

Let fo (x), f,(x),..., fm (x) be differentiable functions defined on a set C c E", and let J (X)
denote the vector (f,(x),..., f,(x))'. Consider the problem yj $ fo (x)(1.1) subject to f (x)< 0.(1.2)

The adenosine class of heterotrimeric guanine nucleotide–binding protein (G protein)–coupled
receptors (GPCRs) mediates the important role of extracellular adenosine in many …