The endoplasmic reticulum (ER) and mitochondria are tightly associated with very dynamic
platforms termed mitochondria-associated membranes (MAMs). MAMs provide an excellent …

Mitochondrial permeability transition (MPT) is the sudden loss in the permeability of the
inner mitochondrial membrane (IMM) to low-molecular-weight solutes. Due to osmotic forces, …

Mitochondria and endoplasmic reticulum (ER) are fundamental in the control of cell
physiology regulating several signal transduction pathways. They continuously communicate …

The impact of the mitochondrial permeability transition ( MPT ) on cellular physiology is well
characterized. In contrast, the composition and mode of action of the permeability transition …

Cardiovascular diseases are one of the leading causes of death. Increasing evidence has
shown that pharmacological or genetic targeting of mitochondria can ameliorate each stage of …

Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the
most dynamic and plastic tissues in the human body and plays a vital role in movement, …

Cardiovascular disease is the most common cause of death worldwide and in particular,
ischemic heart disease holds the most considerable position. Even if it has been deeply studied…

Mitochondria actively contribute to apoptotic cell death through mechanisms including the
loss of integrity of the outer mitochondrial membrane, the release of intermembrane space …

Inter-organelle membrane contact sites are emerging as major sites for the regulation of
intracellular Ca 2+ concentration and distribution. Here, extracellular stimuli operate on a wide …

Aims In the last 15 years, some observations tried to shed light on the dysregulation of the
cellular self-digestion process in calcific aortic valve stenosis (CAVS), but the results obtained …