Sexual neurosteroids (SN), namely 17β-estradiol (E2) and 5α-dehydrotestosterone (DHT),
are synthesized in the hippocampus, where they induce circuit modifications by changing the …

Hippocampal neurons are capable of synthesizing estradiol de novo. Estradiol synthesis
can be suppressed by aromatase inhibitors and by knock-down of steroid acute regulatory …

Estrogens have been described to induce synaptogenesis in principal neurons of the
hippocampus and have been shown to be synthesized and released by exactly these neurons. …

In general, hippocampal neurons are capable of synthesizing sex steroids de novo from
cholesterol, since the brain is equipped with all the enzymes required for the synthesis of …

… Janine Prange-Kiel, Hubertus Jarry, Michael Schoen, Patrick Kohlmann, Christina Lohse,
Lepu Zhou, Gabriele M. Rune; Gonadotropin-releasing hormone regulates spine density via its …

Previous studies have shown that estrogens, originating from ovaries, have a wide variety of
estrogen receptor (ER)‐mediated effects in the hippocampus. In the present study, we have …

Inhibitors of aromatase, the final enzyme of estradiol synthesis, are suspected of inducing
memory deficits in women. In previous experiments, we found hippocampal spine synapse …

Recently, inhibition of estrogen synthesis by aromatase inhibitors has become a favored
therapy for breast cancer in postmenopausal women. Estrogen is, however, important for …

Cholesterol of glial origin promotes synaptogenesis (Mauch et al.,(2001) Science 294: 1354–1357).
Because in the hippocampus local estradiol synthesis is essential for …

A high intracellular chloride concentration in immature neurons leads to a depolarizing action
of GABA that is thought to shape the developing neuronal network. We show that GABA-…