… e Used to assess glycemic variability 12, which can also be assessed as glycemic lability …
e Clinically, benefits of maintaining and monitoring β-cell graft function may outweigh risks of …

Incredible strides have been made since the discovery of insulin almost 100 years ago. Insulin
formulations have improved dramatically, glucose levels can be measured continuously, …

Skeletal muscle size is regulated by anabolic (hypertrophic) and catabolic (atrophic) processes.
We first characterized molecular markers of both hypertrophy and atrophy and identified …

Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify
candidate molecular mediators of muscle atrophy, we performed transcript profiling. Although …

… found in type II, fast fibers (Figure 1E). MuRF1 was found to be capable of immunoprecipitating
MYH… cells (Figure 1E). These data demonstrate that MuRF1 physically interacts with MYH. …

Ubiquitin-conjugation targets numerous cellular regulators for proteasome-mediated
degradation. Thus, the identification of ubiquitin ligases and their physiological substrates is …

… Evidence specifically implicating activin A, as opposed to activin B or C or E, came from the
observation that mice deficient in one allele encoding activin A (Inhba +/− ), but not deficient …

… of cyclin E, but only in its free, non-Cdk2 bound form, whereas cyclin E complexed to Cdk2
is not affected by Skp2 (10). Skp2-deficient cells show high levels of p27 and free cyclin E, …

… 1 E). In contrast, the muscles expressing the nonfunctional Myc-ΔR-MuRF1 decreased in
weight by … UbcH5 clone for expression in E. coli was provided by Dr. Kazuhiro Iwai (Osaka City …

Genetic alterations in the p53 and mdm2 genes have been reported to occur in soft tissue
sarcomas. This study was designed to determine the prevalence and potential clinical value of …