Decreasing glucagon action lowers the blood glucose and may be useful therapeutically for
diabetes. However, interrupted glucagon signaling leads to α cell proliferation. To identify …

Exposure to pesticides has been suggested to increase the risk of Parkinson's disease (PD),
but the mechanisms responsible for this association are not clear. Here, we report that …

Glucagon is a critical regulator of glucose homeostasis; however, mechanisms regulating
glucagon action and α-cell function and number are incompletely understood. To elucidate the …

Glucagon and its partner insulin are dually linked in both their secretion from islet cells and
their action in the liver. Glucagon signaling increases hepatic glucose output, and …

The peptide hormone glucagon, discovered in late 1922, is secreted from pancreatic alpha
cells and is an essential regulator of metabolic homeostasis. This review summarises …

Identification of cell-surface markers specific to human pancreatic β cells would allow in vivo
analysis and imaging. Here we introduce a biomarker, ectonucleoside triphosphate …

Since the discovery of glucagon 100 years ago, the hormone, and the pancreatic islet alpha
cells that produce it, have remained enigmatic relative to insulin producing beta cells. …

Posttransplantation diabetes mellitus (PTDM) is a common and significant complication
related to immunosuppressive agents required to prevent organ or cell transplant rejection. To …

We evaluated the potential for a monoclonal antibody antagonist of the glucagon receptor (Ab-4)
to maintain glucose homeostasis in type 1 diabetic rodents. We noted durable and …

Mitochondria are required for energy production and even give brown adipose tissue (BAT)
its characteristic color due to their high iron content and abundance. The physiological …