Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by
the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential …

Iron is an essential metal for cell survival that is regulated by the peptide hormone hepcidin.
However, its influence on certain diseases is directly related to iron metabolism or …

Oxysterols are oxidized derivatives of cholesterol produced by enzymatic activity or non-enzymatic
pathways (auto-oxidation). The oxidation processes lead to the synthesis of about 60 …

Infection by the protozoan Trypanosoma cruzi causes Chagas disease cardiomyopathy (CCC)
and can lead to arrhythmia, heart failure and death. Chagas disease affects 8 million …

Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on
several cells, organs, and systems in the body. Oxysterols also have an influence on the …

Background Eugenol (EUG) is a major phenolic compound present in clove whose anti-cancer
properties have been demonstrated previously. These anti-cancer properties may …

Aging is defined as the accumulation of progressive organ dysfunction. There is much evidence
linking the involvement of oxidative stress in the pathogenesis of aging. With increasing …

Aging is characterized by a progressive increase in oxidative stress, which favors lipid
peroxidation and the formation of cholesterol oxide derivatives, including 7β-hydroxycholesterol (…

Cardiac transplantation of adipose-derived stem cells (ASC) modulates the post-myocardial
infarction (post-MI) repair response. Biomolecules secreted or shuttled within extracellular …

Among neglected tropical diseases, leishmaniasis is one of the most important ones, affecting
more than 12 million people worldwide. The available treatments are not well tolerated, …