Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside
mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS function as “…

There is a growing consensus that the various forms of cell death (necrosis, apoptosis and
autophagy) are not separated by strict boundaries, but rather share molecular effectors and …

Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux
of low molecular weight solutes (molecular weight up to 1,500) across the generally …

Many cellular processes require the proper cooperation between mitochondria and the
endoplasmic reticulum (ER). Several recent works show that their functional interactions rely on …

Calcium ions (Ca 2+ ) are some of the most versatile signalling molecules, and they have
many physiological functions, prominently including muscle contraction, neuronal excitability, …

Since 1929, when it was discovered that ATP is a substrate for muscle contraction, the
knowledge about this purine nucleotide has been greatly expanded. Many aspects of cell …

The heterogenous subcellular distribution of a wide array of channels, pumps and exchangers
allows extracellular stimuli to induce increases in cytoplasmic Ca 2+ concentration ([Ca 2…

The term “mitochondrial permeability transition” (MPT) refers to an abrupt increase in the
permeability of the inner mitochondrial membrane to low molecular weight solutes. Due to …

The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures,
as they intimately communicate, forming very dynamic platforms termed mitochondria-…

Mitochondria are key decoding stations of the apoptotic process. In support of this view, a
large body of experimental evidence has unambiguously revealed that, in addition to the well-…