Several lines of research on mood disorders reveal that depression involves a dysfunction in
an affective fronto-limbic circuitry that involves the prefrontal cortices, the cingulate cortex,
several limbic structures including the amygdala and the hippocampus, lower brainstem
structures and the basal ganglia. In dealing with both depressive symptoms as well as their
manifestation in the brain, clinical as well as basic research has emphasized mainly a top-
down or central approach in elucidating the etiology of depression and its therapy. The�…

Depression is one of the most prevalent and devastating psychopathologies humanity faces
with no algorithmic cure based on the present pharmacotheraputic techniques and
exclusively central approach to its pathogenesis and therapy. This book provides strong
evidence that a comprehensive assessment of both the etiology and therapeutics of
depression requires an integrative view of how affect and mood are modulated by both
peripheral and central affective mechanisms. Specifically, sensorimotor stimulation via the�…